Lumasiran sodium
Lumasiran sodium is a medication specifically designed to treat primary hyperoxaluria type 1 (PH1), a rare genetic disorder. It is marketed under the brand name Oxlumo by Alnylam Pharmaceuticals.
Mechanism of Action[edit | edit source]
Lumasiran sodium works by inhibiting the production of a protein called glycolate oxidase (GO). This protein is involved in the production of oxalate, a substance that can form crystals in the kidneys and other organs in people with PH1. By reducing the levels of GO, lumasiran sodium decreases the amount of oxalate produced, thereby reducing the risk of crystal formation and kidney damage.
Uses[edit | edit source]
Lumasiran sodium is used to treat PH1 in pediatric and adult patients. It is administered via subcutaneous injection.
Side Effects[edit | edit source]
Common side effects of lumasiran sodium include injection site reactions, abdominal pain, and nausea. Serious side effects can include allergic reactions and kidney problems.
Approval[edit | edit source]
Lumasiran sodium was approved by the U.S. Food and Drug Administration (FDA) in November 2020. It is the first treatment approved by the FDA specifically for PH1.
See Also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
