Luminespib
Luminespib (INN,[1] previously known as NVP-AUY922) is an experimental drug candidate for the treatment of cancer. It was discovered through a collaboration between The Institute of Cancer Research and the pharmaceutical company Vernalis[2] and licensed to Novartis.[3] From 2011 to 2014 it was in Phase II clinical trials.[4][5] Chemically it is a resorcinylic isoxazole amide[5]
Luminespib is an inhibitor of heat shock protein 90 (Hsp90),[6] which is a chaperone protein that plays a role in the modification of a variety of proteins that have been implicated in oncogenesis. Luminespib has shown promising activity in preclinical testing against several different tumor types.[7][8][9][10]
A related compound, NVP-HSP990, was abandoned by Novartis in 2012 after it failed to show efficacy in an early clinical trial.[5]
See also[edit | edit source]
References[edit | edit source]
- ↑ "WHO Drug Information. International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 70" (PDF). World Health Organization. pp. 297–8. Retrieved 16 July 2016.
- ↑ "Structure-based design of cancer therapeutics" (PDF). The Institute of Cancer Research.
- ↑ "AUY922". Vernalis. Archived from the original on 2011-09-29.
{{cite web}}: Unknown parameter|deadurl=ignored (help) - ↑ "Small caps: Vernalis drug fillip". Financial Times. July 19, 2011.
{{cite web}}: Italic or bold markup not allowed in:|publisher=(help) - ↑ 5.0 5.1 5.2
- ↑ Cite error: Invalid
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- ↑
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