Lys-MDA

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Overview[edit | edit source]

Lys-MDA is a compound formed by the reaction of malondialdehyde (MDA) with lysine residues in proteins. This reaction is a type of protein modification that occurs during lipid peroxidation, a process associated with oxidative stress. Lys-MDA adducts are often used as biomarkers for oxidative damage in biological systems.

Structure[edit | edit source]

Chemical structure of Lys-MDA.

The structure of Lys-MDA consists of a malondialdehyde moiety covalently bonded to the _-amino group of a lysine residue. This modification alters the chemical properties of the lysine side chain, potentially affecting the protein's function and stability.

Formation[edit | edit source]

Lys-MDA is formed during the process of lipid peroxidation, where polyunsaturated fatty acids in cell membranes undergo oxidative degradation. Malondialdehyde is one of the end products of this degradation and can react with lysine residues in proteins to form stable adducts.

Biological Significance[edit | edit source]

The formation of Lys-MDA adducts is significant because it can lead to changes in protein function and contribute to the pathogenesis of various diseases. These adducts are often used as indicators of oxidative stress in conditions such as atherosclerosis, diabetes, and neurodegenerative diseases.

Detection and Measurement[edit | edit source]

Lys-MDA adducts can be detected and quantified using various analytical techniques, including mass spectrometry and enzyme-linked immunosorbent assay (ELISA). These methods allow researchers to assess the extent of oxidative damage in biological samples.

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Contributors: Prab R. Tumpati, MD