MAGEA10
MAGEA10 is a gene that encodes a protein in humans. It is a member of the MAGE family, which stands for Melanoma Antigen Family A. The MAGEA10 gene is located on the X chromosome and is expressed in a variety of tissues, including the testis and placenta.
Function[edit | edit source]
The protein encoded by the MAGEA10 gene is a member of the MAGE family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. They are highly expressed in a variety of tumors, including melanoma, breast cancer, and lung cancer.
Clinical significance[edit | edit source]
Due to its high expression in various types of cancer, MAGEA10 is considered a potential target for cancer immunotherapy. Studies have shown that MAGEA10-specific cytotoxic T lymphocytes can recognize and kill tumor cells expressing this antigen.
Research[edit | edit source]
Research is ongoing to develop therapies that target MAGEA10 and other members of the MAGE family. These therapies aim to stimulate the immune system to recognize and destroy tumor cells.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
