MAPK8

MAPK8 or Mitogen-Activated Protein Kinase 8 is a protein that in humans is encoded by the MAPK8 gene. It is also known as JNK1 or c-Jun N-terminal kinase. This protein is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.

Function

The protein encoded by the MAPK8 gene is a member of the MAP kinase family. These kinases are known to play a critical role in many cellular processes including cell proliferation, differentiation, survival and death. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, MAPK8 translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets.

Clinical Significance

Alterations in the function of MAPK8 have been associated with several diseases, including cancer, diabetes, and neurodegenerative diseases. In cancer, MAPK8 has been found to be overexpressed in a variety of tumors, and its activity has been linked to cancer cell survival and proliferation. In diabetes, MAPK8 has been implicated in the development of insulin resistance. In neurodegenerative diseases, MAPK8 has been found to be activated in response to neuronal stress, leading to cell death.

Research

Research into the function and regulation of MAPK8 is ongoing, with the aim of developing targeted therapies for diseases in which MAPK8 plays a role. Several inhibitors of MAPK8 have been developed and are currently in clinical trials.

See Also

• MAP kinase
• Cancer
• Diabetes
• Neurodegenerative diseases