MDA-MB-435

MDA-MB-435 is a cell line that is commonly used in biomedical research. It was originally thought to be a breast cancer cell line, but subsequent research has suggested that it may actually be a melanoma cell line.

History

The MDA-MB-435 cell line was first established in the 1970s from a metastatic lesion in a female patient. It was initially classified as a breast cancer cell line and has been widely used in breast cancer research. However, in the late 1990s and early 2000s, several studies suggested that MDA-MB-435 may actually be derived from a melanoma.

Characteristics

MDA-MB-435 cells are adherent and have a spindle-shaped morphology. They express markers associated with both breast cancer and melanoma, which has contributed to the controversy over their origin. They are highly invasive and metastatic in animal models, making them a useful tool for studying the biology of cancer metastasis.

Controversy

The classification of MDA-MB-435 as a breast cancer or melanoma cell line has been a subject of debate in the scientific community. Some researchers continue to use it as a model for breast cancer, while others argue that it should be reclassified as a melanoma cell line. This controversy has implications for the interpretation of past research and the design of future studies.

Applications

Despite the controversy over its origin, MDA-MB-435 is widely used in cancer research. It is a popular model for studying the mechanisms of cancer metastasis and testing new anti-cancer drugs. It has also been used in studies of cancer stem cells and cancer immunotherapy.

See also

• Cell line
• Breast cancer
• Melanoma
• Cancer metastasis
• Cancer stem cell
• Cancer immunotherapy

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