MEOX2

MEOX2 (also known as Mesenchyme Homeobox 2) is a protein that in humans is encoded by the MEOX2 gene. This protein is a member of the homeobox family of genes, which play a critical role in body structure development during early embryogenesis.

Function

MEOX2 is a transcription factor that is essential for the development of the somite, a structure that gives rise to important tissues such as muscle, bone, and cartilage. It is also involved in the regulation of cell proliferation and differentiation.

Clinical Significance

Mutations in the MEOX2 gene have been associated with Klippel-Feil syndrome, a rare disorder characterized by the fusion of two or more cervical vertebrae. This can lead to a variety of symptoms, including short neck, low hairline at the back of the head, and limited movement of the upper spine.

Research

Research into MEOX2 has potential implications for the treatment of various diseases. For example, it has been suggested that MEOX2 could be a target for cancer therapy, as it has been found to be overexpressed in certain types of cancer.

See Also

• Homeobox
• Klippel-Feil syndrome
• Transcription factor

References

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