MIR200C

MIR200C or miR-200c is a member of the microRNA family, specifically the miR-200 family. MicroRNAs are small non-coding RNA molecules that regulate gene expression post-transcriptionally. MIR200C has been implicated in various biological processes and diseases, including cancer, fibrosis, and embryonic development.

Function

MIR200C primarily functions as a regulator of epithelial-mesenchymal transition (EMT), a process that is crucial for embryonic development and wound healing, but is also involved in pathological conditions such as fibrosis and cancer metastasis. By targeting the ZEB1 and ZEB2 transcription factors, MIR200C inhibits EMT and promotes the maintenance of an epithelial phenotype.

Role in Cancer

In the context of cancer, MIR200C has been shown to act as a tumor suppressor in various types of cancer, including breast cancer, ovarian cancer, and lung cancer. It inhibits cancer cell migration and invasion, and its expression is often downregulated in cancer tissues. However, the role of MIR200C in cancer is complex and may vary depending on the specific type and stage of cancer.

Role in Fibrosis

MIR200C also plays a role in the development of fibrosis, a pathological process characterized by excessive deposition of extracellular matrix proteins. In pulmonary fibrosis, MIR200C has been shown to inhibit the differentiation of fibroblasts into myofibroblasts, a key event in the progression of fibrosis.

Clinical Significance

Given its roles in EMT, cancer, and fibrosis, MIR200C has potential as a diagnostic and prognostic biomarker, as well as a therapeutic target. However, further research is needed to fully understand its functions and therapeutic potential.

MicroRNAs, such as MIR200C, regulate gene expression post-transcriptionally.

See Also

• MicroRNA
• Epithelial-mesenchymal transition
• ZEB1
• ZEB2

References

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