MIRLET7F2

MIRLET7F2 is a gene that in humans encodes the microRNA let-7f-2. MicroRNAs (miRNAs) are short non-coding RNA molecules, containing about 22 nucleotides, that function in RNA silencing and post-transcriptional regulation of gene expression. The MIRLET7F2 gene is part of the let-7 family of miRNAs, which are highly conserved across species.

Function

The MIRLET7F2 gene is responsible for the production of the let-7f-2 microRNA. This microRNA, like others in the let-7 family, is involved in the regulation of gene expression. It does this by binding to the 3' untranslated regions (3' UTRs) of target mRNAs, leading to their degradation or preventing their translation into protein. The let-7 family of miRNAs has been implicated in a variety of biological processes, including cell differentiation, proliferation, and apoptosis.

Clinical Significance

Alterations in the expression of the MIRLET7F2 gene and the let-7f-2 microRNA it produces have been associated with a number of diseases, including various types of cancer. For example, reduced expression of let-7f-2 has been observed in lung cancer and breast cancer, suggesting that it may function as a tumor suppressor. Conversely, overexpression of let-7f-2 has been linked to poor prognosis in colorectal cancer. Further research is needed to fully understand the role of MIRLET7F2 and let-7f-2 in disease development and progression.

See Also

• MicroRNA
• Gene expression
• RNA silencing