MKK7

MKK7 (also known as Mitogen-activated protein kinase kinase 7) is an enzyme that in humans is encoded by the MAP2K7 gene. This gene is a member of the MAPKK family and functions in a signaling cascade controlling cellular responses to cytokines and stress.

Function

MKK7 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses.

Clinical significance

Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions

MKK7 has been shown to interact with:

• MAPK8IP3
• MAP3K1
• MAPK8
• MAPK9
• MAP3K2
• MAP3K7
• MAP4K2

See also

• Mitogen-activated protein kinase
• MAP kinase kinase

External links

• MKK7 at the US National Library of Medicine Medical Subject Headings (MeSH)

MKK7 Resources
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