MKK7
MKK7 (also known as Mitogen-activated protein kinase kinase 7) is an enzyme that in humans is encoded by the MAP2K7 gene. This gene is a member of the MAPKK family and functions in a signaling cascade controlling cellular responses to cytokines and stress.
Function[edit | edit source]
MKK7 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses.
Clinical significance[edit | edit source]
Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Interactions[edit | edit source]
MKK7 has been shown to interact with:
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- MKK7 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
