MNT (gene)

MNT (gene) is a gene that in humans is encoded by the MNT protein. It is a member of the Myc/Max/Mad network, which plays a fundamental role in cellular growth, differentiation, and apoptosis.

Function

The MNT gene encodes a protein that functions as a transcriptional repressor. This protein forms a complex with Max, a protein known to interact with Myc, and is a component of the Myc/Max/Mad network. This network is involved in the regulation of cell cycle progression and cell differentiation. The MNT protein can repress Myc target gene expression, which may prevent the uncontrolled cellular proliferation induced by Myc.

Clinical significance

Alterations in the MNT gene have been associated with various cancer types. Overexpression of MNT has been observed in lung cancer, breast cancer, and colorectal cancer. It is thought that the MNT protein may play a role in tumorigenesis by repressing the transcription of genes that inhibit cell proliferation.

See also

• Myc (gene)
• Max (gene)
• Mad (gene)

External links

• MNT at the National Center for Biotechnology Information

This article incorporates text from the United States National Library of Medicine, which is in the public domain.