MSin3 interaction domain

MSin3 interaction domain (also known as SID) is a protein domain that is found in a variety of proteins. It is named after the protein MSin3, with which it interacts. The domain is involved in the regulation of gene expression and is found in both eukaryotic and prokaryotic organisms.

Structure

The MSin3 interaction domain is typically composed of around 30 amino acids. It forms a helix-turn-helix structure, which allows it to interact with other proteins. The domain is often found in proteins that are involved in the regulation of gene expression, such as transcription factors and chromatin remodeling proteins.

Function

The primary function of the MSin3 interaction domain is to mediate interactions between proteins. It does this by binding to the PAH2 domain of the MSin3 protein. This interaction is crucial for the regulation of gene expression, as it allows the MSin3 protein to recruit other proteins to the DNA and influence the transcription of genes.

In addition to its role in gene expression, the MSin3 interaction domain is also involved in other cellular processes. For example, it has been found to play a role in cell cycle regulation and apoptosis.

Clinical significance

Mutations in the MSin3 interaction domain can lead to a variety of diseases. For example, mutations that disrupt the interaction between the domain and the MSin3 protein can lead to abnormal gene expression and ultimately to diseases such as cancer.

See also

• Protein domain
• Gene expression
• Transcription (genetics)
• Cell cycle
• Apoptosis

References

MSin3 interaction domain Resources
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