MT-TE

MT-TE or Mitochondrial tRNA Threonine is a gene that in humans is encoded by the MT-TE genetic sequence. This gene is a member of the mitochondrial DNA (mtDNA) tRNA family and plays a crucial role in the protein synthesis within the mitochondria.

Function

The MT-TE gene provides instructions for making a molecule called transfer RNA (tRNA) which is essential for assembling amino acids into functioning proteins. Specifically, the MT-TE gene produces a tRNA molecule that helps incorporate the amino acid threonine into proteins. This process is a critical part of the mitochondrial protein synthesis.

Clinical significance

Mutations in the MT-TE gene have been associated with several mitochondrial disorders, including Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) and Myoclonic Epilepsy with Ragged Red Fibers (MERRF). These conditions often involve muscle weakness and pain, seizures, and problems with movement and balance.

See also

• Mitochondrial DNA
• Mitochondrial disease
• tRNA
• Protein synthesis

References

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