MT-TN

MT-TN is a gene that encodes for the mitochondrial tRNA for asparagine. This gene is located within the mitochondrial DNA and is crucial for the proper functioning of the cell.

Function

The MT-TN gene is responsible for the production of a type of transfer RNA (tRNA) that helps in the assembly of proteins within the cell. Specifically, it assists in the incorporation of the amino acid asparagine into growing protein chains. This process is essential for the normal functioning of the mitochondria, the energy-producing centers of the cell.

Clinical significance

Mutations in the MT-TN gene have been associated with a variety of mitochondrial disorders, including Leber's hereditary optic neuropathy (LHON), mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). These conditions are characterized by a wide range of symptoms, from vision loss and muscle weakness to severe neurological problems.

Research

Research into the MT-TN gene and its associated disorders is ongoing. Scientists are particularly interested in understanding how mutations in this gene lead to the diverse symptoms seen in mitochondrial disorders. This knowledge could potentially lead to new treatments for these conditions.

See also

• Mitochondrial DNA
• Transfer RNA
• Mitochondrial disease
• Leber's hereditary optic neuropathy
• Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes