MTA1
MTA1 or Metastasis Associated 1 is a protein that in humans is encoded by the MTA1 gene. It is a part of the nuclear receptor co-repressor complex and plays a significant role in gene expression and cellular differentiation, proliferation, and apoptosis.
Function[edit | edit source]
MTA1 is a component of the NuRD, a multisubunit complex which couples histone deacetylase activity and nucleosome remodeling activity. The protein encoded by this gene is thought to play a role in the regulation of transcription and is known to be a potent suppressor of metastasis.
Clinical significance[edit | edit source]
MTA1 has been found to be upregulated in a number of cancer types, including breast cancer, prostate cancer, and colorectal cancer. Its overexpression has been linked to increased metastatic potential and poor prognosis in these cancers.
Research[edit | edit source]
Research into MTA1 is ongoing, with studies focusing on its role in cancer progression and potential as a target for cancer therapy.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
