Mammaglobin-B

Mammaglobin-B is a protein that in humans is encoded by the SCGB2A2 gene, also known as the mammaglobin-B gene. It belongs to the secretoglobin family of small secreted proteins. This protein plays a significant role in the biology of the mammary gland and has been studied extensively in the context of breast cancer.

Function

Mammaglobin-B is primarily expressed in mammary gland tissue and is involved in the secretory function of the mammary epithelia. The exact physiological role of mammaglobin-B is not fully understood, but it is believed to be involved in the immune response and may have a protective function in the mammary gland. Its expression is hormone-regulated, indicating a potential role in the hormonal control of breast tissue development and function.

Clinical Significance

Mammaglobin-B has gained attention in the field of oncology, particularly in breast cancer research. Its overexpression has been observed in a significant proportion of breast cancer cases, making it a potential biomarker for the disease. The detection of mammaglobin-B mRNA in the blood and lymph nodes of breast cancer patients has been explored as a method for diagnosing and monitoring the disease. Additionally, its limited expression in normal tissues outside the mammary gland makes mammaglobin-B a candidate for targeted therapy, although more research is needed to fully understand its potential in this area.

Genetic

The SCGB2A2 gene encoding mammaglobin-B is located on chromosome 11q12.1. Mutations in this gene and its expression levels have been studied in relation to breast cancer susceptibility and prognosis. However, the genetic mechanisms regulating mammaglobin-B expression and its role in breast cancer development are still under investigation.

Research Directions

Future research on mammaglobin-B is focused on elucidating its biological function, the regulation of its expression, and its interaction with other molecules in the mammary gland. Understanding these aspects is crucial for developing mammaglobin-B-based diagnostic tools and therapies for breast cancer. Studies are also exploring the potential of mammaglobin-B as a biomarker for other types of cancer and its role in the immune response.

See Also

• Breast cancer
• Biomarker
• Oncology
• Gene expression