Mantle zone

Mantle zone (or mantle region) is a term used in histology to describe a part of a lymph node. It is also known as the follicular mantle, and it surrounds the germinal center of a lymphatic follicle. The mantle zone is primarily composed of small lymphocytes, which are a type of white blood cell.

Etymology

The term "mantle" is derived from the Latin word "mantellum", which means "cloak". This is a fitting description, as the mantle zone 'cloaks' or surrounds the germinal center of a lymphatic follicle.

Structure

The mantle zone is located in the outer region of the lymphatic follicle, encircling the germinal center. It is primarily composed of small lymphocytes, which are a type of white blood cell. These lymphocytes are densely packed and form a dark band that can be clearly distinguished under a microscope.

Function

The primary function of the mantle zone is to produce B cells, which are a type of lymphocyte that plays a crucial role in the body's immune response. B cells are produced in the bone marrow and then migrate to the mantle zone, where they mature and differentiate into plasma cells and memory B cells. These cells are then able to produce antibodies in response to an infection.

Clinical significance

Abnormalities in the mantle zone can lead to a variety of medical conditions. For example, Mantle cell lymphoma is a type of non-Hodgkin lymphoma that originates in the mantle zone. This is a rare and aggressive form of cancer that is often difficult to treat.

See also

• Lymph node
• Germinal center
• Lymphocyte
• Mantle cell lymphoma

References

• 
  Dark, light, mantle and marginal zones of a secondary follicle
• Mantle zone
  Mantle zone
• 
  Mantle zone