Matrilin-2
Matrilin-2 is a protein that in humans is encoded by the MATN2 gene. It is a member of the matrilin family, which plays a significant role in the extracellular matrix (ECM) of connective tissues. Matrilin-2 is particularly important for the formation and maintenance of various tissues, including cartilage, bone, and the interstitial matrix of the peripheral nervous system.
Structure[edit | edit source]
Matrilin-2 is a large, multidomain protein that consists of one von Willebrand factor A domain, four epidermal growth factor (EGF)-like domains, and one coiled-coil domain. This structure allows matrilin-2 to engage in multiple interactions with other ECM proteins, such as collagens, proteoglycans, and other matrilins, facilitating the assembly of the ECM and influencing tissue structure and function.
Function[edit | edit source]
The primary function of matrilin-2 is to mediate the interactions between cells and the ECM, a critical aspect of tissue organization, integrity, and repair. By binding to other ECM components, matrilin-2 contributes to the formation of a complex and highly organized network that supports tissue architecture and function. Additionally, matrilin-2 has been implicated in various cellular processes, including cell adhesion, migration, and proliferation, which are essential for tissue development, maintenance, and repair.
Clinical Significance[edit | edit source]
Alterations in the expression or structure of matrilin-2 have been associated with several pathological conditions. For instance, aberrant expression of matrilin-2 has been observed in various forms of cancer, including breast cancer, lung cancer, and glioma, suggesting a role in tumorigenesis and cancer progression. Furthermore, due to its involvement in ECM organization, matrilin-2 has been studied in the context of fibrotic diseases and tissue repair, indicating its potential as a therapeutic target in fibrosis and wound healing processes.
Research[edit | edit source]
Ongoing research is focused on elucidating the precise mechanisms by which matrilin-2 contributes to tissue homeostasis and pathology. Studies employing genetic models, such as Matn2 knockout mice, have provided valuable insights into the role of matrilin-2 in development and disease. Additionally, investigations into the interactions between matrilin-2 and other ECM components are shedding light on the complex network of protein-protein interactions that underlie ECM function and stability.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD