Melanocortin 5 receptor

Melanocortin 5 receptor (MC5R) is a protein that in humans is encoded by the MC5R gene. It is a member of the melanocortin receptor family, a group of G protein-coupled receptors that are involved in a wide variety of physiological functions.

Structure

The MC5R protein is a 325 amino acid residue protein that is primarily expressed in exocrine glands. The protein is a seven-transmembrane domain receptor, which is a common structure for G protein-coupled receptors. The gene encoding this protein is located on the long arm of chromosome 18 (18q22).

Function

MC5R is involved in a variety of physiological functions. It is known to play a role in exocrine function, as it is expressed in many exocrine glands. It is also involved in the regulation of immune system responses and has been implicated in the control of hair follicle differentiation.

Clinical significance

Mutations in the MC5R gene have been associated with a variety of conditions. For example, a mutation in this gene has been linked to obesity in mice, suggesting a potential role in the regulation of body weight. Additionally, MC5R has been implicated in the pathogenesis of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis.

Research

Research into the function and potential therapeutic applications of MC5R is ongoing. Some studies suggest that MC5R could be a target for the treatment of obesity and autoimmune diseases. However, more research is needed to fully understand the role of this receptor in health and disease.

See also

• Melanocortin receptor
• G protein-coupled receptor
• Exocrine gland
• Autoimmune disease

References

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