Membranoproliferative

Membranoproliferative glomerulonephritis (MPGN) is a type of glomerulonephritis, a group of diseases that cause inflammation and damage to the kidney's filtering units. These disorders are typically characterized by changes in the kidney that are visible under a microscope.

Overview

MPGN is a rare condition that primarily affects children and young adults. This disease is also known as mesangiocapillary glomerulonephritis, and it can lead to kidney failure if not treated promptly.

Causes

The exact cause of MPGN is unknown, but it is often associated with conditions that can damage the kidneys. These include autoimmune diseases, chronic infections, and certain blood disorders.

Symptoms

The symptoms of MPGN can vary, but they often include blood in the urine (hematuria), protein in the urine (proteinuria), and decreased kidney function. Some people may also experience fatigue, loss of appetite, and swelling in the legs and ankles.

Diagnosis

MPGN is typically diagnosed through a combination of blood tests, urine tests, and a kidney biopsy. The biopsy, which involves taking a small sample of kidney tissue for examination under a microscope, can reveal the characteristic changes in the kidney that are indicative of MPGN.

Treatment

Treatment for MPGN focuses on controlling the symptoms and slowing the progression of the disease. This may involve medications to control high blood pressure and reduce proteinuria, as well as treatments for any underlying conditions that may be contributing to the kidney damage.

Prognosis

The prognosis for people with MPGN varies. Some people may experience progressive kidney damage and eventually require dialysis or a kidney transplant, while others may have a more benign course of the disease.

See also

• Glomerulonephritis
• Kidney disease
• Kidney failure
• Autoimmune diseases

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