Mesembrine

Mesembrine is an alkaloid present in the Sceletium tortuosum plant, also known as Kanna. It is believed to contribute to the mood-enhancing effects of the plant. Mesembrine serves as a serotonin reuptake inhibitor and a PDE4 inhibitor, which are both mechanisms associated with antidepressant effects.

Chemistry[edit | edit source]

Mesembrine is a type of alkaloid, a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms. This alkaloid is found in the Sceletium tortuosum plant, which is native to South Africa.

Pharmacology[edit | edit source]

The primary mechanism of action for Mesembrine is as a serotonin reuptake inhibitor. This means it prevents the reabsorption of serotonin into the presynaptic cell, increasing the amount of serotonin available to bind to the postsynaptic receptor. It also acts as a PDE4 inhibitor, which is a mechanism associated with antidepressant effects.

Uses[edit | edit source]

Traditionally, Sceletium tortuosum has been used for its mood-enhancing effects, and mesembrine is believed to contribute to these effects. However, more research is needed to fully understand the potential uses and benefits of mesembrine.

Safety[edit | edit source]

While Sceletium tortuosum has been used traditionally for centuries, the safety of mesembrine, particularly in high doses or over long periods of time, is not well studied. As with any substance, it should be used responsibly and under the guidance of a healthcare professional.

See also[edit | edit source]

Mesembrine Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.