Mesothelin

Mesothelin is a protein that in humans is encoded by the MSLN gene. It is a cell surface glycoprotein predominantly associated with mesothelial cells and overexpressed in several forms of cancer, including mesothelioma and ovarian cancer.

Function

Mesothelin is thought to play a role in cell adhesion and is present on the cell surface of mesothelial cells, which line the body's serous cavities and internal organs. It is also found in the pleura, peritoneum, and pericardium, and is overexpressed in certain cancers.

Clinical significance

Mesothelin is a biomarker for several types of cancer, including mesothelioma and ovarian cancer. It is overexpressed in these cancers, which makes it a potential target for cancer therapy. Several therapies targeting mesothelin are currently in clinical trials.

See also

• Mesothelioma
• Ovarian cancer
• Cancer therapy

External links

• Mesothelin at the US National Library of Medicine Medical Subject Headings (MeSH)

Mesothelin Resources
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