Metadoxine

Metadoxine, also known as pyridoxine-pyrrolidone carboxylate, is a drug used primarily to treat alcohol intoxication. Metadoxine accelerates alcohol clearance from the blood and is used in acute alcohol intoxication and in the treatment of alcoholic liver disease.

Pharmacology

Metadoxine is a complex of pyridoxine (vitamin B6) and pyrrolidone carboxylate. The drug works by accelerating the metabolic degradation of alcohol and improving the functional status of the liver. It increases the rate at which the liver metabolizes alcohol and eliminates it from the body.

Medical uses

Metadoxine is used in the treatment of acute and chronic alcoholism. It is used to accelerate the elimination of alcohol from the blood and to treat the functional and organic changes caused by chronic alcoholism, especially those affecting the liver.

Side effects

The most common side effects of metadoxine include nausea, vomiting, stomach pain, and diarrhea. Less common side effects include allergic reactions, headache, and dizziness.

History

Metadoxine was developed in the 1980s and has been used in Europe and Asia for many years. It was approved for medical use in the United States in 2019.

See also

• Alcohol intoxication
• Alcoholic liver disease
• Pyridoxine
• Pyrrolidone carboxylate

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