Metalloendopeptidase
| Metalloendopeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24 | ||||||||
| CAS number | 9025-06-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Metalloendopeptidases are a type of endopeptidase that require a metal ion for their catalytic activity. These enzymes are part of the larger family of metalloproteases, which are characterized by their dependence on metal ions, typically zinc or cobalt, to hydrolyze peptide bonds in proteins.
Function[edit | edit source]
Metalloendopeptidases play crucial roles in various biological processes, including protein degradation, cell signaling, and tissue remodeling. They are involved in the breakdown of extracellular matrix components, which is essential for processes such as wound healing, angiogenesis, and metastasis of cancer cells.
Mechanism[edit | edit source]
The catalytic mechanism of metalloendopeptidases involves the coordination of a metal ion at the active site of the enzyme. This metal ion acts as a Lewis acid, stabilizing the negative charge on the carbonyl oxygen of the peptide bond, thereby facilitating nucleophilic attack by a water molecule. The resulting tetrahedral intermediate is then resolved, leading to the cleavage of the peptide bond.
Classification[edit | edit source]
Metalloendopeptidases are classified based on their structure and the type of metal ion they utilize. The most common classification system is the MEROPS database, which groups these enzymes into different families and clans based on sequence similarity and structural features.
Examples[edit | edit source]
Some well-known examples of metalloendopeptidases include:
Clinical Significance[edit | edit source]
Metalloendopeptidases are targets for therapeutic intervention in various diseases. Inhibitors of MMPs, for example, are being investigated for their potential to treat cancer, arthritis, and cardiovascular diseases. Neprilysin inhibitors are used in the treatment of heart failure.
Related Pages[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
