Metaproterenol sulfate
Metaproterenol Sulfate is a bronchodilator medication used in the treatment of asthma, chronic obstructive pulmonary disease (COPD), and other respiratory conditions. It is a synthetic sympathomimetic amine that primarily acts on beta-adrenergic receptors in the lungs to relax and open air passages, making it easier for patients to breathe.
Pharmacology[edit | edit source]
Metaproterenol Sulfate is a non-selective beta-adrenergic agonist, meaning it stimulates both beta-1 adrenergic receptors and beta-2 adrenergic receptors. Its primary therapeutic effect is achieved through activation of beta-2 receptors in the bronchial smooth muscle, leading to bronchodilation. This action helps to alleviate symptoms such as wheezing, shortness of breath, and chest tightness associated with respiratory conditions.
Clinical Use[edit | edit source]
Metaproterenol Sulfate is used in the management of reversible bronchospasm associated with obstructive airway diseases, including asthma and COPD. It can be administered via oral inhalation or nebulization. The medication is typically used on an as-needed basis to relieve acute symptoms, but it may also be used regularly to prevent symptoms in chronic conditions.
Side Effects[edit | edit source]
Common side effects of Metaproterenol Sulfate include tachycardia, palpitations, nervousness, tremor, and headache. These are generally related to the drug's stimulation of beta-1 receptors in the heart and central nervous system. Serious side effects, although rare, can include cardiac arrhythmias, hypertension, and severe allergic reactions.
Contraindications[edit | edit source]
Metaproterenol Sulfate is contraindicated in patients with known hypersensitivity to the drug or its components. It should be used with caution in patients with cardiovascular disorders, hyperthyroidism, diabetes mellitus, and seizure disorders due to the potential for exacerbation of these conditions.
Interactions[edit | edit source]
Metaproterenol Sulfate may interact with other medications, including other sympathomimetic agents, beta-blockers, and monoamine oxidase inhibitors. These interactions can lead to increased side effects or decreased therapeutic effects.
See Also[edit | edit source]
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