Metenkefalin

Metenkefalin is a naturally occurring opioid peptide that has potent pain relieving effects, comparable to those of morphine. It is one of the two forms of enkephalin, the other being leu-enkephalin. Metenkefalin is derived from the proenkephalin gene and is composed of five amino acid residues, Tyr-Gly-Gly-Phe-Met.

Structure and Function

Metenkefalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met), meaning it is composed of five amino acids. It is produced and stored in various parts of the brain and spinal cord, and is released in response to certain types of stress or pain.

Metenkefalin binds to the opioid receptors in the brain and spinal cord, specifically the delta opioid receptor. This binding action inhibits the release of GABA, a neurotransmitter that normally inhibits the release of dopamine. By inhibiting GABA, metenkefalin allows for more dopamine to be released, which leads to feelings of pleasure and pain relief.

Clinical Significance

Metenkefalin has been studied for its potential use in the treatment of various conditions, including chronic pain, depression, and certain immune disorders. It has also been investigated for its potential role in addiction treatment, as it may help to alleviate withdrawal symptoms and reduce cravings.

Research

Research into the potential therapeutic uses of metenkefalin is ongoing. Some studies have suggested that it may have anti-inflammatory effects, and could potentially be used to treat conditions such as rheumatoid arthritis. Other research has focused on its potential use in the treatment of neuropathic pain.

See Also

• Enkephalin
• Opioid peptide
• Pain management