ADAMTS8

ADAMTS8 (A Disintegrin And Metalloproteinase with Thrombospondin Motifs 8) is a protein that in humans is encoded by the ADAMTS8 gene. This protein is part of the ADAMTS family, which is known for its role in various biological processes, including cell adhesion, proteolysis, and angiogenesis.

Function

ADAMTS8 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises aggrecan and versican.

Clinical significance

ADAMTS8 has been implicated in a variety of diseases, particularly cancer. Reduced expression of this gene has been associated with various types of cancers, including lung cancer, breast cancer, and colorectal cancer. It is believed to act as a tumor suppressor by inhibiting angiogenesis.

Research

Research into ADAMTS8 is ongoing, with studies focusing on its role in cancer progression and potential as a therapeutic target. It is also being studied for its role in other diseases, such as rheumatoid arthritis and osteoarthritis.

See also

• ADAMTS family
• Angiogenesis
• Tumor suppressor