Methantheline bromide

Methantheline bromide is a muscarinic antagonist with antispasmodic properties. It is used in the treatment of peptic ulcer disease and gastrointestinal spasms. Methantheline bromide works by blocking the action of acetylcholine, a neurotransmitter that can induce spasms in the gastrointestinal tract.

Pharmacology

Methantheline bromide is a quaternary ammonium compound that acts as a non-selective muscarinic antagonist. It inhibits the action of acetylcholine on muscarinic receptors, thereby reducing the tone and motility of the gastrointestinal tract. This results in a decrease in spasms and provides relief from the symptoms of peptic ulcer disease and gastrointestinal spasms.

Clinical Use

Methantheline bromide is used in the management of peptic ulcer disease and gastrointestinal spasms. It is also used in the treatment of irritable bowel syndrome (IBS) and other conditions where a reduction in gastrointestinal motility is desired.

Side Effects

Common side effects of methantheline bromide include dry mouth, blurred vision, and urinary retention. Less common side effects include constipation, tachycardia, and dizziness. As with all medications, the benefits of treatment should be weighed against the potential risks.

Contraindications

Methantheline bromide is contraindicated in patients with glaucoma, myasthenia gravis, and severe ulcerative colitis. It should also be used with caution in patients with prostatic hypertrophy or urinary retention.

Interactions

Methantheline bromide may interact with other medications, including other anticholinergic drugs, antihistamines, and tricyclic antidepressants. These interactions can increase the risk of side effects and should be considered when prescribing methantheline bromide.

See Also

• Muscarinic antagonist
• Peptic ulcer disease
• Gastrointestinal spasms
• Irritable bowel syndrome

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