Methenamine hippurate

Methenamine hippurate is a pharmaceutical drug used primarily in the treatment and prevention of urinary tract infections (UTIs). It is a compound of methenamine, an antibacterial agent, and hippuric acid, a natural acid found in the urine.

Pharmacology

Methenamine hippurate works by decomposing at an acidic pH to form formaldehyde and ammonia. The formaldehyde is toxic to bacteria, which helps to eliminate the infection. The hippurate component of the drug also has some antibacterial properties and helps to acidify the urine.

Uses

Methenamine hippurate is used to prevent recurrent UTIs, especially in individuals who have chronic issues with these infections. It is also used in the treatment of acute UTIs, although it is not a first-line treatment.

Side Effects

Like all medications, methenamine hippurate can cause side effects. These can include nausea, vomiting, and diarrhea. In rare cases, it can cause a severe allergic reaction.

Interactions

Methenamine hippurate can interact with other medications, including sulphonamides and anticholinergic drugs. It is important to inform healthcare providers of all medications being taken when starting a new medication.

Contraindications

Methenamine hippurate should not be used in individuals with severe liver disease, kidney disease, or dehydration. It is also contraindicated in individuals who are allergic to any component of the drug.

Dosage

The dosage of methenamine hippurate varies depending on the individual and the condition being treated. It is typically taken orally, with the dose adjusted based on the severity of the infection and the individual's response to treatment.

See Also

• Urinary tract infections
• Methenamine
• Hippuric acid