Calusterone

Calusterone

Calusterone (INN, also known as 7β,17α-dimethyltestosterone) is a synthetic, orally active androgen and anabolic steroid (AAS) which was never marketed. It is a derivative of testosterone, more specifically a closely related analogue of methyltestosterone, differing by the addition of a methyl group at the C7 position. Calusterone has been studied in the treatment of patients with breast cancer and as an antineoplastic agent in the 1970s, but it was never approved for medical use.

Medical Uses

Calusterone was investigated for potential medical uses, particularly in the treatment of breast cancer in women. Clinical studies in the 1970s evaluated its effectiveness in this context, but it did not proceed to market for this or any other indication.

Pharmacology

Pharmacodynamics

As an androgen and anabolic steroid, calusterone has similar effects to testosterone in the body, promoting muscle growth and development of male sexual characteristics. However, due to its structural modifications, it may have different potency and side effects compared to testosterone and other AAS.

Pharmacokinetics

The pharmacokinetic profile of calusterone, including its absorption, distribution, metabolism, and excretion, has not been well-characterized due to its limited clinical development.

Chemistry

Calusterone is a synthetic steroid and a derivative of testosterone. It is specifically a modified form of methyltestosterone, with a methyl group added at the C7 position. This modification potentially alters its activity and metabolism compared to its parent compound.

History

Calusterone was developed and studied in the 1970s as a potential treatment for breast cancer. Despite initial research, it did not advance to later stages of clinical trials or receive approval for clinical use. The reasons for this include the emergence of more effective treatments and possibly the adverse effects associated with androgen and anabolic steroid use.

Society and Culture

Legal Status

The legal status of calusterone varies by country, but it is not approved for medical use or available on the market in any known jurisdiction. It may be classified similarly to other androgen and anabolic steroids, which are controlled substances in many countries due to their potential for abuse and adverse health effects.

See Also

• Anabolic steroid
• Methyltestosterone
• Testosterone