Methoxyketamine

Methoxyketamine is a research chemical in the arylcyclohexylamine class. It is an analog of ketamine where the chlorine group has been replaced by a methoxy group.

Chemistry

Methoxyketamine belongs to the class of organic compounds known as arylcyclohexylamines, which are compounds containing a cyclohexylamine moiety attached to an aromatic group. The systematic name of methoxyketamine is 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone.

Pharmacology

The pharmacology of methoxyketamine is not well-studied. However, it is known to act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them, which leads to disconnection of neurons and results in loss of feeling, difficulty moving, and eventually this substance can cause a K-hole, a state of extreme disconnection from reality.

Legality

The legality of methoxyketamine varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use. It is always recommended to check the legal status in your own country before possession or distribution.

Safety

As with all research chemicals, the safety profile of methoxyketamine is not well-established. It is recommended to use harm reduction practices when using this substance, including using a test kit to confirm the identity of the substance, starting with a low dose, and having a sober trip sitter present.

See also

• Ketamine
• Research chemical
• Arylcyclohexylamine
• NMDA receptor antagonist