Methylcobalamin

Methylcobalamin is a form of vitamin B12. It is one of the two coenzyme forms of B12, the other being adenosylcobalamin. Methylcobalamin is used in the treatment of pernicious anemia, vitamin B12 deficiency, and can also be given as part of a regimen for megaloblastic anemia.

Chemistry

Methylcobalamin features a methyl group (CH3) attached to the cobalt atom. In the body, it is converted from cyanocobalamin, a synthetic form of vitamin B12. Methylcobalamin is involved in the healthy functioning of the brain and nervous system, and the formation of red blood cells.

Medical uses

Methylcobalamin is used to treat vitamin B12 deficiency, a condition in which the body does not absorb enough vitamin B12 from food. This can lead to pernicious anemia, a type of anemia that can cause symptoms such as fatigue, weakness, and shortness of breath.

In addition, methylcobalamin is used in the treatment of megaloblastic anemia, a blood disorder in which the bone marrow produces unusually large, structurally abnormal, immature red blood cells (megaloblasts).

Side effects

Common side effects of methylcobalamin include headache, nausea, and diarrhea. In rare cases, it can cause more serious side effects such as allergic reactions.

See also

• Cobalamin
• Vitamin B12 deficiency
• Pernicious anemia
• Megaloblastic anemia