Methyldesorphine

Methyldesorphine is a semi-synthetic opioid analgesic developed in the 1940s. It is structurally related to desomorphine, a derivative of morphine. Methyldesorphine is less potent than morphine but more potent than codeine. It has been used in the treatment of severe pain, often for post-operative pain management.

Chemistry

Methyldesorphine, also known as 3-methyl-6-desoxy-7,8-dihydro-6-desoxymorphine, is a semi-synthetic opioid derived from morphine. It is a member of the phenanthrene group of opioids, which also includes morphine, codeine, and desomorphine. The chemical structure of methyldesorphine is similar to that of morphine, with the addition of a methyl group at the 3 position.

Pharmacology

Methyldesorphine acts primarily as an agonist at the mu-opioid receptor, the main site of action for the most commonly used opioids. It has a high affinity for this receptor, which is responsible for its analgesic effects. Methyldesorphine also has a lower affinity for the kappa-opioid receptor and the delta-opioid receptor, which may contribute to its analgesic and sedative effects.

Clinical Use

Methyldesorphine has been used in the treatment of severe pain, often for post-operative pain management. It is typically administered via injection. Due to its potency and potential for addiction, it is classified as a Schedule II controlled substance in the United States.

Side Effects

Like other opioids, methyldesorphine can cause a range of side effects, including nausea, vomiting, constipation, and respiratory depression. It can also cause physical dependence and addiction with long-term use.

See Also

• Opioid
• Morphine
• Desomorphine
• Codeine