Methylergonovine maleate

Methylergonovine Maleate is a semi-synthetic ergot alkaloid used for the prevention and control of postpartum hemorrhage, a condition characterized by heavy bleeding after childbirth. It is also used for the management of post-abortion hemorrhage.

Pharmacology

Methylergonovine maleate acts on the smooth muscle of the uterus, causing it to contract. It achieves this by stimulating the uterine muscle receptors, leading to increased rhythmic contractions. This helps to control bleeding and hasten the return of the uterus to its normal size after childbirth or abortion.

Administration and Dosage

Methylergonovine maleate can be administered orally, intramuscularly, or intravenously. The dosage and route of administration depend on the patient's condition and the physician's judgment. It is important to note that this medication should only be used when medically necessary and under the supervision of a healthcare professional.

Side Effects

Like all medications, methylergonovine maleate can cause side effects. These may include nausea, vomiting, abdominal pain, and headache. In rare cases, serious side effects such as hypertension, seizures, and stroke may occur. Patients should seek immediate medical attention if they experience any unusual or severe side effects.

Contraindications

Methylergonovine maleate is contraindicated in patients with hypersensitivity to ergot alkaloids, and in conditions where a rapid increase in blood pressure might have detrimental effects, such as pre-eclampsia, eclampsia, and hypertension.

Interactions

Methylergonovine maleate may interact with other medications, including those used for migraine, HIV, and certain types of cancer. It is important for patients to inform their healthcare provider of all the medications they are currently taking.

See Also

• Ergot Alkaloids
• Postpartum Hemorrhage
• Post-Abortion Hemorrhage

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