Methylfluorophosphonylcholine

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Methylfluorophosphonylcholine (MFPC) is a chemical compound that belongs to the class of organophosphates. It is a synthetic compound that has been studied for its potential use in various applications, including as a neurotransmitter inhibitor and a potential nerve gas agent.

Chemical Structure[edit | edit source]

MFPC is composed of a methyl group (CH3), a fluorine atom (F), a phosphorus atom (P), and a choline group (C5H14NO). The phosphorus atom is bonded to the fluorine atom and the methyl group, forming a phosphonate group. The phosphonate group is then bonded to the choline group, forming the complete MFPC molecule.

Properties and Synthesis[edit | edit source]

MFPC is a colorless, odorless liquid at room temperature. It is highly reactive and can easily form bonds with other molecules. The synthesis of MFPC involves the reaction of dimethyl methylphosphonate with fluorine gas in the presence of a catalyst, followed by the addition of choline.

Applications[edit | edit source]

The primary application of MFPC is in the field of neuroscience. It acts as an inhibitor of the neurotransmitter acetylcholine, which plays a key role in the functioning of the nervous system. By inhibiting acetylcholine, MFPC can affect nerve signal transmission, making it a potential nerve gas agent.

However, the use of MFPC as a nerve gas is highly controversial and is subject to strict regulations under the Chemical Weapons Convention. Research is ongoing to explore other potential applications of MFPC, including its use in the treatment of neurological disorders such as Alzheimer's disease and Parkinson's disease.

Safety and Toxicity[edit | edit source]

Due to its potential use as a nerve gas, MFPC is classified as a highly toxic substance. Exposure to MFPC can cause a range of symptoms, including difficulty breathing, blurred vision, and loss of consciousness. Long-term exposure can lead to permanent damage to the nervous system.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD