Metynodiol diacetate

Metynodiol diacetate is a progestin medication which is used in hormone therapy. It is a derivative of progesterone and was introduced for medical use in the 1960s. Metynodiol diacetate is taken by mouth.

Pharmacology

Metynodiol diacetate is a progestogen, or an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak androgenic and estrogenic activity and no other important hormonal activity. The medication is a prodrug of noretynodrel, which is also a progestin.

Medical uses

Metynodiol diacetate is used as a component of menopausal hormone therapy to prevent endometrial hyperplasia and uterine cancer in women who are taking estrogens. It is also used in the treatment of gynecological disorders.

Side effects

Side effects of metynodiol diacetate include menstrual irregularities, nausea, breast tenderness, headache, and acne. It can also cause weight gain and mood changes.

History

Metynodiol diacetate was introduced for medical use in the 1960s. It is marketed widely throughout the world.

Society and culture

Metynodiol diacetate is marketed under a variety of brand names including Demulen, Cyclessa, and others.

See also

• List of progestogens
• List of progestogen esters