MicroRNA 517c

MicroRNA 517c (miR-517c) is a small non-coding RNA molecule that regulates gene expression. It belongs to the larger family of microRNAs, which are involved in a wide range of biological processes, including development, differentiation, apoptosis, and proliferation.

Function

MicroRNA 517c functions by binding to the 3' untranslated regions (3' UTRs) of target mRNAs, leading to their degradation or translational repression. This post-transcriptional regulation allows miR-517c to control the expression of various genes and participate in numerous cellular processes.

Role in Cancer

Several studies have implicated miR-517c in the development and progression of various types of cancer. For instance, it has been found to be overexpressed in ovarian cancer cells, where it promotes cell proliferation and inhibits apoptosis by targeting the tumor suppressor gene PTEN. Similarly, in lung cancer, miR-517c has been shown to promote cell migration and invasion by targeting the epithelial-mesenchymal transition (EMT) suppressor gene, E-cadherin.

Clinical Significance

Due to its role in cancer, miR-517c has potential as a diagnostic and prognostic biomarker. Its overexpression in cancer tissues compared to normal tissues suggests that it could be used to distinguish cancer patients from healthy individuals. Moreover, its association with cancer progression and poor prognosis indicates that it could be used to predict patient outcomes.

Therapeutic Potential

Given its oncogenic role, miR-517c is also being explored as a potential therapeutic target. Strategies to inhibit its function, such as antisense oligonucleotides and small molecule inhibitors, are currently under investigation. These could potentially be used in combination with existing therapies to improve treatment outcomes.

File:MicroRNA.png

MicroRNA molecule, of which miR-517c is a member.

See Also

• MicroRNA
• Non-coding RNA
• Ovarian cancer
• Lung cancer

References

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