Migration-stimulating factor

Migration-stimulating factor (MSF) is a protein that in humans is encoded by the MSF gene. MSF is a fibronectin-binding protein and has the ability to stimulate cell migration, hence its name. It is a member of the kringle protein family and plays a significant role in wound healing, angiogenesis, and tumor growth.

Function

MSF is a potent stimulator of cell migration, and it is involved in the remodelling of tissue architecture. It is secreted by fibroblasts and endothelial cells, and it acts by binding to fibronectin, a high-molecular-weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins.

Clinical significance

MSF has been implicated in a variety of pathological conditions. It is overexpressed in many cancers, including breast cancer, lung cancer, and colorectal cancer, and it is thought to contribute to tumor growth and metastasis by promoting angiogenesis and cell migration.

In addition, MSF has been found to be upregulated in chronic wounds, suggesting a role in wound healing. It is thought to promote the migration of fibroblasts and endothelial cells into the wound area, thereby facilitating tissue repair.

See also

• Fibronectin
• Kringle
• Angiogenesis
• Tumor growth
• Cell migration
• Wound healing