Monoaminergic activity enhancer

Overview

Chemical structure of Selegiline, a monoaminergic activity enhancer

A monoaminergic activity enhancer (MAE) is a type of compound that enhances the activity of monoamine neurotransmitters in the brain. These neurotransmitters include dopamine, serotonin, and norepinephrine. MAEs are distinct from monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs) in their mechanism of action.

Mechanism of Action

MAEs work by increasing the release of monoamines from presynaptic neurons and enhancing their activity at the synaptic cleft. Unlike MAOIs, which prevent the breakdown of monoamines, MAEs facilitate the natural release and action of these neurotransmitters. This can lead to increased neurotransmission and improved mood and cognitive function.

Examples of Monoaminergic Activity Enhancers

One of the most well-known MAEs is Selegiline, also known as L-deprenyl. Selegiline is primarily used in the treatment of Parkinson's disease and major depressive disorder. It selectively inhibits monoamine oxidase B (MAO-B) at lower doses, but at higher doses, it acts as an MAE, enhancing dopaminergic and other monoaminergic activity.

Clinical Applications

MAEs have potential applications in the treatment of various neurological and psychiatric disorders. By enhancing monoaminergic activity, they may improve symptoms of depression, cognitive decline, and other mood disorders. Selegiline, for example, is used to manage symptoms of Parkinson's disease by increasing dopaminergic activity, which is typically reduced in this condition.

Side Effects and Considerations

While MAEs can be beneficial, they may also have side effects, including insomnia, nausea, and dizziness. It is important for clinicians to monitor patients for any adverse effects and adjust dosages accordingly. Additionally, interactions with other medications, particularly those affecting monoamine levels, should be carefully managed.

Related Pages

• Monoamine neurotransmitter
• Dopamine
• Serotonin
• Norepinephrine
• Selegiline
• Parkinson's disease
• Major depressive disorder