Myeloid/erythroid ratio

Myeloid/Erythroid ratio (also known as M/E ratio) is a calculation used in the field of hematology to assess the proportion of myeloid cells to erythroid cells in the bone marrow. This ratio is often used as a diagnostic tool to identify various blood disorders and bone marrow diseases.

Overview

The myeloid/erythroid ratio is a measure of the relative number of myeloid cells (which include neutrophils, eosinophils, basophils, monocytes, and platelets) to erythroid cells (which include red blood cells and their precursors) in the bone marrow. The normal M/E ratio in humans is approximately 2:1 to 4:1, but this can vary depending on the individual's age and overall health.

Clinical significance

Changes in the M/E ratio can indicate various health conditions. An increased M/E ratio may be indicative of conditions such as myeloproliferative disorders, chronic myeloid leukemia, or polycythemia vera. Conversely, a decreased M/E ratio may suggest conditions such as aplastic anemia, myelodysplastic syndromes, or erythroleukemia.

Measurement

The M/E ratio is typically determined through a bone marrow biopsy, which involves the removal of a small amount of bone marrow tissue for examination under a microscope. The cells are then counted and the ratio is calculated.

See also

• Complete blood count
• Hematopoiesis
• Myeloid cell
• Erythroid cell