Myofibroblast

Myofibroblast is a type of cell that is associated with the process of wound healing and fibrosis. These cells are characterized by their contractile nature, which is similar to that of smooth muscle cells. They are also known for their role in the production of extracellular matrix components, such as collagen and fibronectin.

Origin

Myofibroblasts originate from several sources, including fibroblasts, pericytes, endothelial cells, and epithelial cells. The exact origin of these cells can vary depending on the tissue and the type of injury or disease.

Function

The primary function of myofibroblasts is to facilitate wound closure by contracting the wound edges. They achieve this through the formation of stress fibers, which are bundles of actin and myosin filaments that generate contractile force. In addition to their contractile function, myofibroblasts also contribute to the formation of the extracellular matrix, which provides structural support to the tissue.

Role in disease

While myofibroblasts play a crucial role in wound healing, their persistence can lead to pathological conditions such as fibrosis and cancer. In fibrosis, the excessive production of extracellular matrix by myofibroblasts can lead to the thickening and scarring of tissues. In cancer, myofibroblasts can promote tumor growth and invasion by remodeling the extracellular matrix and producing growth factors.

See also

• Fibroblast
• Wound healing
• Fibrosis
• Cancer

Myofibroblast Resources
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