N'-formylkynurenine
N'-formylkynurenine is an intermediate compound in the metabolism of tryptophan, an essential amino acid. It is formed from tryptophan through the action of the enzyme tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO).
Structure and Properties[edit | edit source]
N'-formylkynurenine is a carboxylic acid with a formyl group attached to the nitrogen atom of the kynurenine molecule. It is a polar compound due to the presence of the carboxylic acid and formyl groups, which also make it soluble in water.
Role in Tryptophan Metabolism[edit | edit source]
In the metabolism of tryptophan, N'-formylkynurenine is an important intermediate. The conversion of tryptophan to N'-formylkynurenine is the first and rate-limiting step in the kynurenine pathway, which is the major route of tryptophan degradation in the body. This step is catalyzed by the enzymes TDO and IDO.
Clinical Significance[edit | edit source]
Alterations in the levels of N'-formylkynurenine and other kynurenine pathway metabolites have been associated with various diseases, including cancer, neurodegenerative diseases, and immune disorders. In particular, increased activity of IDO and elevated levels of kynurenine pathway metabolites are often observed in cancer patients and are thought to contribute to immune suppression.
See Also[edit | edit source]
.svg){kind=small}
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
