N-Acetyl-γ-aminobutyric acid
N-Acetyl-γ-aminobutyric acid (NAGB) is a derivative of the neurotransmitter gamma-aminobutyric acid (GABA). It is a compound of interest in the field of neurochemistry due to its potential role in modulating neurotransmission and its presence in various biological systems.
Chemical Structure and Properties[edit | edit source]
N-Acetyl-γ-aminobutyric acid is a small organic molecule with the chemical formula C6H11NO3. It is structurally related to GABA, with an acetyl group attached to the nitrogen atom of the amino group. This modification alters its chemical properties and potential biological activity.
The presence of the acetyl group makes NAGB more lipophilic compared to GABA, which may influence its ability to cross biological membranes, such as the blood-brain barrier.
Biosynthesis and Metabolism[edit | edit source]
N-Acetyl-γ-aminobutyric acid is synthesized in the body through the acetylation of GABA. This reaction is catalyzed by specific acetyltransferase enzymes. The metabolic fate of NAGB in the body is not as well characterized as that of GABA, but it is believed to be involved in various metabolic pathways.
Biological Function[edit | edit source]
The exact biological role of N-Acetyl-γ-aminobutyric acid is not fully understood. However, it is hypothesized to participate in the regulation of GABAergic neurotransmission. As a derivative of GABA, NAGB may interact with GABA receptors or influence the availability of GABA in the synaptic cleft.
Potential Clinical Significance[edit | edit source]
Research into N-Acetyl-γ-aminobutyric acid is ongoing, with interest in its potential therapeutic applications. Its ability to modulate GABAergic activity suggests it could have implications in the treatment of neurological disorders such as epilepsy, anxiety, and depression.
Related Compounds[edit | edit source]
NAGB is part of a broader class of compounds known as GABA analogs, which include other derivatives such as baclofen and gabapentin. These compounds are of interest for their potential to modulate GABAergic activity and their therapeutic applications.
See Also[edit | edit source]
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
