NETO1

NETO1 is a protein that in humans is encoded by the NETO1 gene. NETO1 is a member of the neuropilin (NRP) family and is involved in the development and maintenance of the nervous system.

Function

The NETO1 protein is a component of the NMDA receptor complex, which plays a crucial role in long-term potentiation and synaptic plasticity. It is involved in the regulation of glutamate signaling, which is essential for neural communication, memory formation, and learning.

Structure

The NETO1 protein is composed of 516 amino acids and has a molecular weight of approximately 58 kDa. It contains a single transmembrane domain and two CUB domains, which are thought to be involved in protein-protein interactions.

Clinical significance

Mutations in the NETO1 gene have been associated with a variety of neurological disorders, including schizophrenia, autism, and epilepsy. In addition, alterations in NETO1 expression have been implicated in the pathogenesis of Alzheimer's disease and other neurodegenerative conditions.

Research

Research on NETO1 has focused on its role in synaptic plasticity and its potential as a therapeutic target for neurological disorders. Studies have shown that NETO1 is essential for the proper functioning of the NMDA receptor, and that alterations in NETO1 function can lead to abnormalities in synaptic transmission and neural circuitry.

See also

• Neuropilin
• NMDA receptor
• Synaptic plasticity
• Neurological disorders