NFE2L2

NFE2L2 or Nuclear factor erythroid 2-related factor 2 is a transcription factor that in humans is encoded by the NFE2L2 gene. NFE2L2 induces the expression of various genes including those that encode for antioxidant proteins and phase II detoxification enzymes.

Function

NFE2L2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Clinical significance

Under normal conditions, the NFE2L2 protein is targeted for degradation via ubiquitination by the Keap1-Cul3-Rbx1 E3 ligase complex. However, under oxidative stress conditions, NFE2L2 escapes Keap1-mediated degradation and translocates into the nucleus, where it binds to the Antioxidant Response Element (ARE) located in the promoters of genes coding for antioxidant/detoxifying enzymes and scavengers.

See also

• Keap1
• Cul3
• Rbx1
• Antioxidant Response Element

External links

• NFE2L2 gene on the US National Library of Medicine website.

NFE2L2 Resources
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