NFKBID

NFKBID

NFKBID is a gene that encodes for the IκBNS protein, which is a member of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibitor family. This family of proteins plays a crucial role in regulating the NF-κB pathway, which is involved in inflammation, immune response, cell proliferation, and apoptosis. The NFKBID gene is located on human chromosome 6 and consists of multiple exons that encode for the IκBNS protein.

The IκBNS protein, encoded by NFKBID, functions as an atypical inhibitor of NF-κB. Unlike classical NF-κB inhibitors, which sequester NF-κB in the cytoplasm to prevent its activation, IκBNS can modulate NF-κB activity in the nucleus. It does so by affecting the transcription of specific NF-κB target genes. The precise mechanism of how IκBNS influences NF-κB activity and its target gene specificity is an area of ongoing research.

NFKBID and its product, IκBNS, are implicated in various biological processes and diseases. For instance, alterations in the expression of NFKBID have been associated with certain autoimmune diseases, cancer, and infectious diseases. The role of NFKBID in these conditions is thought to be related to its ability to modulate the immune response and cell survival signals.

Research into NFKBID and IκBNS is ongoing, with studies aimed at understanding their biological functions, regulatory mechanisms, and potential as therapeutic targets in diseases where the NF-κB pathway is dysregulated.