NRG4

NRG4‏‎ is a protein that in humans is encoded by the NRG4 gene. It is a member of the neuregulin protein family which in turn is a part of the EGF family of proteins. NRG4 plays a crucial role in the development and function of multiple organ systems, including the heart, nervous system, and endocrine system.

Function[edit | edit source]

NRG4 is a ligand for the ERBB4 receptor. It is a signaling protein that interacts with the ERBB4 receptor tyrosine kinase to initiate a variety of cellular responses. NRG4 is involved in the regulation of cell growth, survival, differentiation, and also plays a role in the development of the nervous system.

Clinical significance[edit | edit source]

Studies have shown that NRG4 may have a protective role in obesity and type 2 diabetes. It has been suggested that NRG4 could be used as a therapeutic target for metabolic diseases. In addition, NRG4 has been implicated in certain types of cancer, including breast cancer and pancreatic cancer.

References[edit | edit source]

External links[edit | edit source]

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