NRG4
NRG4 is a protein that in humans is encoded by the NRG4 gene. It is a member of the neuregulin protein family which in turn is a part of the EGF family of proteins. NRG4 plays a crucial role in the development and function of multiple organ systems, including the heart, nervous system, and endocrine system.
Function[edit | edit source]
NRG4 is a ligand for the ERBB4 receptor. It is a signaling protein that interacts with the ERBB4 receptor tyrosine kinase to initiate a variety of cellular responses. NRG4 is involved in the regulation of cell growth, survival, differentiation, and also plays a role in the development of the nervous system.
Clinical significance[edit | edit source]
Studies have shown that NRG4 may have a protective role in obesity and type 2 diabetes. It has been suggested that NRG4 could be used as a therapeutic target for metabolic diseases. In addition, NRG4 has been implicated in certain types of cancer, including breast cancer and pancreatic cancer.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
 | This protein-related article is a stub. You can help WikiMD by expanding it. |
 | This gene article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
