NS-2359
NS-2359 (also known as GSK-372,475) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that was under development by GlaxoSmithKline (GSK) for clinical use as an antidepressant, but was discontinued in 2009. It was being investigated for its potential to treat major depressive disorder and as a possible smoking cessation aid.
Pharmacology[edit | edit source]
NS-2359 is a potent inhibitor of the reuptake of serotonin, norepinephrine, and dopamine. This triple reuptake inhibition makes NS-2359 a unique antidepressant. The compound's activity at the three neurotransmitter transporters is believed to confer a superior therapeutic profile compared to traditional SSRIs and SNRIs.
Clinical Trials[edit | edit source]
Phase I and II clinical trials were conducted by GSK to assess the safety, tolerability, and efficacy of NS-2359. However, the development of the drug was discontinued in 2009. The reasons for the discontinuation have not been publicly disclosed.
Potential Uses[edit | edit source]
Despite the discontinuation of its development, NS-2359 has been the subject of independent research due to its unique pharmacological profile. It has been suggested as a potential treatment for a variety of conditions including major depression, generalized anxiety, and as a potential aid in smoking cessation.
See Also[edit | edit source]
- Serotonin-norepinephrine-dopamine reuptake inhibitor
- GlaxoSmithKline
- Antidepressant
- Major depressive disorder
- Smoking cessation
NS-2359 Structure
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
