NT5E

NT5E (5'-Nucleotidase, Ecto) is a protein that in humans is encoded by the NT5E gene. This protein is an enzyme that catalyzes the conversion of purine 5'-mononucleotides to nucleosides, an important process in nucleotide metabolism.

Function

The NT5E protein is a cell surface enzyme that is involved in the regulation of extracellular levels of adenosine and inosine monophosphates. It functions by catalyzing the dephosphorylation of these monophosphates to their corresponding nucleosides. This process is critical for the regulation of tissue homeostasis and cell proliferation.

Clinical significance

Mutations in the NT5E gene have been associated with a variety of medical conditions. For example, they have been linked to calcification of joints and arteries, and early-onset arteriosclerosis, a condition characterized by hardening and loss of elasticity in the arteries. This condition is also known as NT5E deficiency.

Research

Research into the function and potential therapeutic applications of NT5E is ongoing. Some studies suggest that NT5E may play a role in the regulation of immune response, inflammation, and tumor growth. Further research is needed to fully understand these potential roles and their implications for human health.

See also

• 5'-Nucleotidase
• Nucleotide metabolism
• Arteriosclerosis

References

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