Inosine

Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond.

Inosine is commonly found in tRNA and is essential for proper translation of the genetic code in wobble base pairs.

Chemistry[edit | edit source]

Inosine is a purine nucleoside that is formed from adenosine by the action of the enzyme adenosine deaminase. It can be converted back to adenosine by the enzyme purine nucleoside phosphorylase.

Biological role[edit | edit source]

Inosine plays a key role in the wobble hypothesis of genetic code translation. It can pair with adenine, cytosine, and uracil. This allows for a certain degree of flexibility in the pairing of the third base of the codon in mRNA with the first base of the anticodon in tRNA.

Medical use[edit | edit source]

Inosine has been investigated as a possible treatment for Parkinson's disease. It has been shown to have neuroprotective effects in some studies, but further research is needed to confirm these findings.

See also[edit | edit source]

Inosine Resources
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